SeqMaestro: interpretable machine learning links nucleotide sequences to biological hypotheses
A new arXiv paper introduces SeqMaestro, a method that analyzes nucleotide sequences using interpretable machine learning to connect raw sequence data with testable biological hypotheses. The approach aims to combine the interpretability of classical bioinformatics features, such as motifs and k-mer composition, with the predictive power of modern ML models. It targets applications across regulatory genomics, evolutionary biology, and phenotype prediction.