papersSEP 12 04:00 UTC
arXiv Paper Proposes Amortized Adaptive Design for CRISPR Screen Hit Discovery
A new arXiv preprint describes a "biology-in-the-loop" framework that chooses which perturbations to test next when experimental budgets are limited. The approach amortizes the cost of adaptive decision-making so that sequential selection can be applied efficiently to CRISPR screens. The authors frame the problem as sequential experimental design for biological discovery under constrained resources.