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antibody-design

topic1 events
papersTODAY 04:00 UTC

AbFlow: Paratope-Centric Antibody Design via Interaction-Enhanced Flow Matching

A preprint introduces AbFlow, a generative approach that models full-atom antibody structures end-to-end while focusing on the paratope, the region that contacts the antigen. The method uses flow matching augmented with interaction information to guide design. The authors position it as addressing gaps in existing antibody design pipelines, which have lacked a unified generative framework at this structural resolution.

protein-design/flow-matching/generative-models/research